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Lua pe fa tui ole platelet-rich plasma i le tulivae osteoarthritis e leʻi suia ai synovial biomarkers, ae na faʻaleleia atili ai taunuʻuga falemaʻi.

E tusa ai ma le suʻega a tagata tomai faʻapitoa tau pisinisi, na latou faʻatusatusaina le lua ma le fa intra-articular tui o platelet-rich plasma (PRP) e faʻatatau i suiga i synovial cytokines ma taunuʻuga falemaʻi.E 125 tagata gasegase e maua ile osteoarthritis tuli (OA) na maua tui ole PRP ile 6 vaiaso.A'o le'i tu'iina PRP ta'itasi, sa aoina le mana'oga o le sua o le synovial mo su'esu'ega.Na vaevaeina tagata maʻi i ni tui PRP se lua pe fa (vaega A ma B, faʻasologa).Suiga i synovial biomarkers na faʻatusatusa i tulaga faʻavae i vaega uma e lua, ma suʻesuʻega faʻamaʻi i le tausaga e tasi.E ivasefulufa maʻi na faʻamaeʻaina le aoina o le sua o le synovial na aofia i le iloiloga mulimuli, 51 i le vaega A ma le 43 i le vaega B. E leai se eseesega i le fua o tausaga, feusuaiga, faʻasologa o le tino (BMI), ma le radiographic OA grade.Ole fua ole platelet ma le pa'epa'e toto pa'epa'e ile PRP e 430,000/µL ma 200/µL, fa'asologa. Synovial inflammatory cytokines (IL-1β, IL-6, IA-17A, ma TNF-α), anti-inflammatory cytokines (IL -4, IL-10, IL-13, ma le IL-1RA) e leʻi suia, ma le tuputupu aʻe Factors (TGF-B1, VEGF, PDGF-AA ma PDGF-BB) sa i le laina faʻavae ma i le va o 6 vaiaso i le Vaega A ma 18 vaiaso i le Vaega B. O taunuʻuga faʻasoifua maloloina i vaega uma e lua na faʻaleleia atili mai le 6 vaiaso, e aofia ai le Visual Analog Scale (VAS), Patient Reported Outcome Measures [PROMs;Western Ontario ma McMaster Universities Osteoarthritis (WOMAC) Index ma Short Form-12 (SF-12)], fua faʻatatau o faʻatinoga [PBMs;taimi e tu ai i luga (TUG), 5 suʻega nofo-tuʻu (5 × SST), ma suʻega 3-minute savali (3-minute WT)]. I le faaiuga, 2 poʻo le 4 intra-articular injections o le PRP i 6 vaiaso uma ile tulivae OA e leʻi faʻaalia ni suiga i synovial cytokines ma mea faʻatupulaia, ae na faʻaleleia atili ai taunuʻuga mai le 6 vaiaso i le 1 tausaga.


Taimi meli: Mati-03-2022